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Contents:
  1. The role of mitochondria in the pathogenesis of type 2 diabetes.
  2. Mitochondria and cardiovascular diseases—from pathophysiology to treatment
  3. Bibliographic Information

As such, they are crucial to the healthy functioning of cells. Recent research has shown that mitochondrial dysfunction underlies a broad spectrum of disease, from maternally inherited genetic disorders to metabolism defects, aging, stroke, and neurodegenerative diseases such as Parkinson's, Alzheimer's, and Lou Gehrig's disease.

This book brings together top researchers whose work in examining the pathophysiologic processes will lead to new strategies for prevention and treatment. JavaScript is currently disabled, this site works much better if you enable JavaScript in your browser. Life Sciences Cell Biology. Free Preview. Buy eBook.

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The role of mitochondria in the pathogenesis of type 2 diabetes.

About this book Mitochondria are organelles in each cell outside the nucleus and are the energy source of all cells. Increased enzymatic O-GlcNAcylation of mitochondrial proteins impairs mitochondrial function in cardiac myocytes exposed to high glucose. M 33 Kanwar, M. Oxidative damage in the retinal mitochondria of diabetic mice: possible protection by superoxide dismutase. Invest Ophthalmol Vis Sci 48, Renal mitochondrial damage and protein modification in type-2 diabetes. Acta Diabetol 45, Dysfunction of mitochondria in human skeletal muscle in type 2 diabetes.

Diabetes 51, Role of mitochondrial dysfunction in insulin resistance. Circ Res , Tissue specificity of insulin resistance in humans: fat in the liver rather than muscle is associated with features of the metabolic syndrome.


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  • Genome editing in mitochondria corrects a pathogenic mtDNA mutation in vivo!
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Diabetologia 51, Mitochondrial factors in the pathogenesis of diabetes: a hypothesis for treatment. Altern Med Rev 7, Neurobiol Dis 23, Mechanisms of disease: mitochondria as new therapeutic targets in diabetic neuropathy. Nat Clin Pract Neurol 2, Myocardial ischemia selectively depletes cardiolipin in rabbit heart subsarcolemmal mitochondria.


  1. Mitochondria in the pathogenesis of diabetes: a proteomic view.
  2. Modulation of Mitochondria During Viral Infections.
  3. Cardiac mitochondria: description of origin, function, network and biogenesis!
  4. Treatment of diabetic nephropathy with angiotensin II receptor antagonist. Clin Exp Nephrol 7, Proteomic analysis of mitochondria from Caenorhabditis elegans. Proteomics 9, Model of nonalcoholic steatohepatitis. Am J Clin Nutr 79, Proteomics insights into deregulated protein S-nitrosylation and disease. Expert Rev Proteomics 9, Mitochondrial dysfunction and type 2 diabetes. Science , Oxidative stress and diabetic retinopathy: pathophysiological mechanisms and treatment perspectives. Rev Endocr Metab Disord 9, In beta-cells, mitochondria integrate and generate metabolic signals controlling insulin secretion.

    Int J Biochem Cell Biol 38, Role of mitochondria in beta-cell function and dysfunction. Adv Exp Med Biol , Mitochondrial function in normal and diabetic beta-cells. Nature , NF-kappaB-induced oxidative stress contributes to mitochondrial and cardiac dysfunction in type II diabetes.

    Cardiovasc Res 85, Mitochondrial respiration is decreased in skeletal muscle of patients with type 2 diabetes. Heterogeneous bioenergetic behaviour of subsarcolemmal and intermyofibrillar mitochondria in fed and fasted rats. Cell Mol Life Sci 63, PGC-1alpha-responsive genes involved in oxidative phosphorylation are coordinately downregulated in human diabetes. Nat Genet 34, Mitochondria as potential targets in antidiabetic therapy.

    Handb Exp Pharmacol , CoQ10 therapy attenuates amyloid beta-peptide toxicity in brain mitochondria isolated from aged diabetic rats. Exp Neurol , Insulin protects against amyloid beta-peptide toxicity in brain mitochondria of diabetic rats.

    Neurobiol Dis 18, Reduced mitochondrial density and increased IRS-1 serine phosphorylation in muscle of insulin-resistant offspring of type 2 diabetic parents. J Clin Invest , Alteration of renal respiratory Complex-III during experimental type-1 diabetes. BMC Endocr Disord 9, 2. Impact of mitochondrial ROS production in the pathogenesis of diabetes mellitus and its complications.

    Antioxid Redox Signal 9, Normalizing mitochondrial superoxide production blocks three pathways of hyperglycaemic damage. Stable isotope labeling by amino acids in cell culture, SILAC, as a simple and accurate approach to expression proteomics. Mol Cell Proteomics 1, A mitochondrial protein compendium elucidates complex I disease biology. Mitochondrial modulation: reversible phosphorylation takes center stage?

    Trends Biochem Sci 31, Mass spectrometry based glycoproteomics-from a proteomics perspective. Mol Cell Proteomics 10, R Coordinated reduction of genes of oxidative metabolism in humans with insulin resistance and diabetes: Potential role of PGC1 and NRF1. The role of mitochondria in the pathogenesis of type 2 diabetes. Endocr Rev 31, A thousand points of light: the application of fluorescence detection technologies to two-dimensional gel electrophoresis and proteomics.

    Electrophoresis 21, CO;2-E 69 Petersen, K. Impaired mitochondrial activity in the insulin-resistant offspring of patients with type 2 diabetes. N Engl J Med , The relationship between glucose control and the development and progression of diabetic nephropathy. Curr Diab Rep 2, Two-dimensional gel electrophoresis in proteomics: Past, present and future.

    J Proteomics 73, A systematic characterization of mitochondrial proteome from human T leukemia cells. Mol Cell Proteomics 4, Deficiency of subsarcolemmal mitochondria in obesity and type 2 diabetes. Adipocytes as regulators of energy balance and glucose homeostasis. Multiplexed protein quantitation in Saccharomyces cerevisiae using amine-reactive isobaric tagging reagents.

    Mol Cell Proteomics 3, Mitochondrial proteomics and its application in biomedical research. Mol Biosyst 5, Diabetic retinopathy, superoxide damage and antioxidants. Curr Pharm Biotechnol 12, Mitochondrial biogenesis and the development of diabetic retinopathy. Free Radic Biol Med 51, Partial resistance to peroxisome proliferator-activated receptor-alpha agonists in ZDF rats is associated with defective hepatic mitochondrial metabolism.

    Oxidative injury and apoptosis of dorsal root ganglion neurons in chronic experimental diabetic neuropathy. Diabetes 52, Cardiac mitochondrial damage and biogenesis in a chronic model of type 1 diabetes. Mitochondrial dysfunction in diabetes: from molecular mechanisms to functional significance and therapeutic opportunities.

    Antioxid Redox Signal 12, Unraveling the pathogenesis of type 1 diabetes with proteomics: present and future directions. Two subpopulations of mitochondria in the aging rat heart display heterogenous levels of oxidative stress. Free Radic Biol Med 35, Diabetes Res Clin Pract 67, Characterization of the human heart mitochondrial proteome. Nat Biotechnol 21, Damaged mitochondrial DNA replication system and the development of diabetic retinopathy. Antioxid Redox Signal 17, Evidence of undiscovered cell regulatory mechanisms: phosphoproteins and protein kinases in mitochondria.

    Cell Mol Life Sci 59, High glucose disrupts mitochondrial morphology in retinal endothelial cells: implications for diabetic retinopathy. Am J Pathol , Protein tyrosine nitration in the mitochondria from diabetic mouse heart. Implications to dysfunctional mitochondria in diabetes. M 91 Turko, I. Quantitative protein profiling in heart mitochondria from diabetic rats. M 92 Turner, N. Is mitochondrial dysfunction a cause of insulin resistance? Trends Endocrinol Metab 19, Cell Calcium 44, Effects of a high-fat diet on energy metabolism and ROS production in rat liver.

    Mitochondria and cardiovascular diseases—from pathophysiology to treatment

    J Hepatol 54, Mitochondrial diseases in man and mouse. IDF diabetes atlas: global estimates of the prevalence of diabetes for and Diabetes Res Clin Pract 94, Minireview: implication of mitochondria in insulin secretion and action. Endocrinology , Mitochondrial remodeling in adipose tissue associated with obesity and treatment with rosiglitazone. Mitochondrial fission mediates high glucose-induced cell death through elevated production of reactive oxygen species. Cardiovasc Res 79, Mass spectrometry- based label-free quantitative proteomics.

    J Biomed Biotechnol , Global and societal implications of the diabetes epidemic.

    Improved proteome analysis of Saccharomyces cerevisiae mitochondria by free-flow electrophoresis. Proteomics 3, Viewed Full text. Mitochondria in the pathogenesis of diabetes: a proteomic view. Abstract Diabetes mellitus is a complex metabolic disorder characterized by chronic hyperglycemia due to absolute or relative lack of insulin. Corresponding Authors: Yang Fuquan,Email:fqyang sun5. Issue Date: 01 September Cite this article:. E-mail this article.

    Bibliographic Information

    E-mail Alert. Articles by authors. Xiulan Chen. Shasha Wei. Fuquan Yang. Akude, E. Anello, M. Bantscheff, M. Baseler, W. Befroy, D. Bindokas, V. Boudina, S. Boushel, R. Brownlee, M.